The research team led by Christoph Castellani deals with the influence of tumor-associated cachexia and chemotherapy on the intestinal microbiome, metabolism and the intestinal wall barrier. In previous publications, significant changes in the intestinal microbiome composition paired with an inflammatory reaction and increased bowel wall permeability were shown to be caused by the tumor itself (Pediatric Blood and Cancer 2017; IF 2,646) and by its chemotherapy (Pediatric Research 2019; IF 2,747).
We further examine the possibility of modifying the intestinal microbiome - for example with prebiotics or probiotics - in favor of the host. A research project on this topic is currently being carried out in cooperation with the Allergosan Institute, the University of Natural Resources and Life Sciences in Vienna and the Medical University of Rostock and is funded by the Austrian Research Promotion Agency (FFG). Initial findings in this project were able to show a beneficial effect of OMNi LOGiC® Fiber Substitution on the intestinal wall barrier (Nutrients 2020; IF 4,546).
In addition to pre- and probiotics, the research group is interested in the question "is it the bacteria themselves or their metabolites" and in the influence of postbiotics, bacteriocins and antimicrobial bacterial metabolites on the microbiome in general. Possible beneficial effects in the context of chemotherapy and tumor-associated cachexia are investigated.
Funded by: FFG – Austrian Research Promotion Agency, Institut Allergosan, MEFO Graz
Cooperation partners: CBmed Graz, Austria, Reingard Grabherr, Department für Biotechnologie, Universität für Bodenkultur Wien, Österreich, Wolfram Miekisch, Rostock Medical Breath Analysis and Technologies, Universität Rostock, Deutschland